منابع مشابه
Laminin-511
Laminins are major constituents of basement membranes. At least 16 isoforms have now been described, each with distinct spatio-temporal expression patterns and functions. The laminin-511 heterotrimer (α5β1γ1) is one of the more recent isoforms to be identified and a potent adhesive and pro-migratory substrate for a variety of normal and tumor cell lines in vitro. As our understanding of its pre...
متن کاملLaminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells.
Human pluripotent stem cells (hPSCs) have gained a solid foothold in basic research and drug industry as they can be used in vitro to study human development and have potential to offer limitless supply of various somatic cell types needed in drug development. Although the hepatic differentiation of hPSCs has been extensively studied, only a little attention has been paid to the role of the ext...
متن کاملLaminin 511 partners with laminin 332 to mediate directional migration of Madin–Darby canine kidney epithelial cells
Sustained directional migration of epithelial cells is essential for regeneration of injured epithelia. Front-rear polarity of migrating cells is determined by local activation of a signaling network involving Cdc42 and other factors in response to spatial cues from the environment, the nature of which are obscure. We examined the roles of laminin (LM)-511 and LM-332, two structurally different...
متن کاملLaminin 511 Partners with Laminin 332 to Mediate Directional Migration of Madin-Darby Canine Kidney (MDCK) Epithelial Cells
Laminin 511 Partners with Laminin 332 to Mediate Directional Migration of Madin-Darby Canine Kidney (MDCK) Epithelial Cells Patricia G. Greciano, Jose V. Moyano, Mary M. Buschmann, Jun Tang, Yue Lu, Jean Rudnicki , Aki Manninen, and Karl S. Matlin Department of Surgery and Committee on Molecular Medicine, The University of Chicago, Chicago, Illinois 60637, USA Department of Pathology, The Unive...
متن کاملMechanistic basis for the recognition of laminin-511 by a6b1 integrin
Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins—three laminin globular domains of the a chain (LG1–3) and the carboxyl-terminal tail of the g chain (g-tail)—are required for integrin binding, but it remains unclear how the g-tail contributes to the binding. We determined the crystal structure of the integrin binding fragment of laminin-51...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2013
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.22125